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ICAAC 2012: Zinc Finger Gene Therapy Leads to Gains in CD4 T-Cells, Especially Memory Cells

Gene therapy using a zinc finger nuclease that makes CD4 T-cells resistant to HIV infection led to long-term gains in CD4 cell counts among HIV positive people with poor immunological recovery on antiretroviral therapy (ART), researchers reported at the 52nd Interscience Conference on Antimicrobials and Chemotherapy (ICAAC) last week in San Francisco. Transitional memory T-cells appeared to account for most of the increase. 

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Coverage of the 2012 Interscience Conference on Antimicrobial Agents and Chemotherapy

HIVandHepatitis.com coverage of the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, September 9-12, 2012.

Topics highlighted this year include experimental antiretroviral drugs, complications related to HIV and its treatment, recent developments in hepatitis C therapy, cancer caused by HPV, influenza, tuberculosis, and STDs.

Full listing by topic

HIVandHepatitis.com ICAAC 2012 conference section

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AIDS 2012: French Cohort Treated during Primary Infection Appears to Control HIV without ART

A group of French HIV patients known as the VISCONTI cohort, who started antiretroviral therapy (ART) during the earliest stage of infection, so far appear to be controlling the virus after interrupting treatment, researchers reported at the recent XIX International AIDS Conference (AIDS 2012) in Washington, DC.

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Coverage of 2012 Interscience Conference on Antimicrobial Agents and Chemotherapy

HIVandHepatitis.com coverage of the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy -- better known as ICAAC -- in San Francisco, September 9-12, 2012.

Topics highlighted this year include experimental antiretroviral drugs, complications related to HIV and its treatment, recent developments in hepatitis C therapy, and cancer caused by HPV, along with a gamut of other infectious diseases including influenza, tuberculosis, and STDs.

Full listing by topic

HIVandHepatitis.com ICAAC 2012 conference section

9/11/12

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AIDS 2012: HDAC Vorinostat Disrupts HIV Latency in Patients' CD4 Cells

The histone deacetylase inhibitor vorinostat can interfere with a mechanisms that allows HIV to remain latent in resting CD4 T-cells, offering the potential to flush out the virus -- one approach being explored as a potential cure for HIV, researchers reported in the July 25, 2012, issue of Nature and at the XIX International AIDS Conference (AIDS 2012) last week in Washington, DC.alt

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