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CROI 2013: Zinc Finger Gene Therapy Leads to Durable T-Cell Recovery, Sangamo Says

Modification of CD4 T-cells using zinc finger technology designed to render cells resistant to HIV led to durable immune reconstitution, while a different gene therapy technique may make cells less susceptible to viral infection, according to 2 studies presented at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) last week in Atlanta.

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CROI 2013: Early Antiretroviral Therapy May Reduce HIV Reservoir Size [VIDEO]

Starting antiretroviral therapy (ART) very early may restrict the size of the established HIV reservoir in long-lived T-cells, which could ultimately make it easier to achieve a functional cure, according to research presented last week at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) in Atlanta.

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CROI 2013: Very Early Antiretroviral Treatment Limits the Size of HIV Reservoir

Very early antiretroviral treatment may limit the size of the HIV reservoir in adults and children, according to studies presented this week at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) in Atlanta. Other research presented at the meeting suggests that too little is known about either the size or the cell types that constitute the HIV reservoir to be confident that early assessments will be a reliable guide to the potential for viral eradication.

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CROI 2013: HIV Treatment for Children Safe and Highly Effective without Laboratory Monitoring

Children did just as well on antiretroviral therapy (ART) without routine laboratory monitoring of CD4 cell counts or drug side effects as those who received regular monitoring during 4 years of follow-up, researchers from Uganda and Zimbabwe reported at March 6 the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) in Atlanta.

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Coverage of the 2013 Conference on Retroviruses and Opportunistic Infections

HIVandHepatitis.com coverage of the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013), March 3-6, 2013, in Atlanta.

Conference highlights include HIV experimental therapies and treatment strategies, HIV cure research, HIV-related conditions and complications, treatment as prevention and PrEP, new treatments for hepatitis C, and HIV/HBV and HIV/HCV coinfection.

Full listing by topic

HIVandHepatitis.com CROI 2013 conference section

3/4/13

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